We propose to use ISO to measure the far-infrared spectral energy distributions of a large sample of high redshift quasars. These quasars have been selected to all have a redshift between 2.0 and 3.0, the epoch at which the co-moving space density of quasars peaks. This will be the most complete far-infrared study of high luminosity, high redshift quasars performed to date, and will be used to compare the range in far-infrared-to-optical/UV luminosity ratios in these objects to that seen in quasars studied at low redshift with the IRAS. These observations will give us a detailed picture of the global variation of the infrared-to-optical/UV luminosity ratio among high redshift quasars, and be fundamental for our understanding of quasar as well as galaxy evolution. This proposal is part of a large ongoing project to measure the far-infrared, near-infrared, and optical properties of a large sample of both low and high redshift quasars.