We propose to use ISO to study the FIR energy distribution and to determine the FIR luminosity function for high redshift(z$>$4) radio quiet QSOs as part of a systematic investigation into the molecular content, dust mass, dust emissivity and dynamics of high redshift objects. The targets will be selected from a sample of the known ~60 radio quiet QSOs with z$>$4. Observing priorities will be based on their ISO visibility, optical luminosities, and previous submm/mm observations at the IRAM 30m and JCMT to maximise the scientific impact. NOTE: THIS PROPOSAL IS NOT ASKING FOR TIME TO OBSERVE ALL 48 TARGETS THAT ARE LISTED IN THE OBSERVATION_SUMMARY_FORM. TIME IS REQUESTED FOR 10 TARGETS.