Observations of two neon fine structure lines will give the absolute neon abundance and its radial gradient in H II regions in the disk of the spiral galaxy M 33. This will serve as a check on the model- dependent abundances derived from visible lines. Nucleosynthesis models predict that the neon abundance should track the oxygen abundance. If it does not, photoionization models for H II regions or the nucleosynthesis models must be wrong. Only ISO has the sensitivity to observe the lines in the relatively diffuse H II regions known in M 33, and the [Ne III] line is not observable from the ground, aircraft, or even from balloons.