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We propose ISOPHOT observations of 20 mixed morphology pairs of galaxies (elliptical plus spiral/irregular). The pairs are selected from the Catalog of Isolated Pairs of Galaxies (CPG: Karachentsev 1972). Mixed pairs provide a unique way to examine a restricted part of the parameter space relating interactions and star formation. They represent pairs where a single gas rich disk galaxy is perturbed by a bulge dominated companion. Thus the orientation of the respective angular momentum axes becomes relatively unimportant (compared to S+S pairs). The IR emission from mixed type pairs can also shed light on mechanisms that lead to secular evolution of the binary components. The role of one mechanism, cross-fuelling in binary systems, is explored in this proposal. Mixed pairs are the only sample for which it is possible to establish the existence and influence of cross-fuelling in an unambiguous way. We would like to observe a statistically useful sample of about twenty mixed pairs at five different wavelengths: 11.3, 15, 60, 100 and 160 microns. The sample contains isolated CPG mixed pairs that are FIR bright, accordant in redshift and with component separations as small as feasible. Combined with observations of normal spiral and elliptical galaxy samples, our survey can reveal any differences in MIR and FIR emission that are related to interaction and subsequent secular evolution in binary galaxies.